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. 2021 May 26;9:675503. doi: 10.3389/fcell.2021.675503

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Copyright © 2021 Li, Qu, Zhu, Wang, He, Xie, Wu and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CGRP levels were decreased in the bone marrow supernatant of mice during aging. (A) RT-qPCR analysis of the mRNA level of Calca in bone tissue of mice at 3, 6, 9, 12, 15, 18, 21, and 24 months of age (n = 5 per age group). (B) The relative levels of CGRP in bone marrow supernatant were measured by ELISA. *P < 0.05, ***P < 0.001.