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The surface-exposed, network residue Ala198 is remote from both the αTS active site and the αTS-βTS interface. Structures of (A) the αTS subunit (PDB ID Code: 2RH9), highlighting catalytic residues Glu49 and Asp60, the substrate IGP, and Ala198, and (B) the full tryptophan synthase complex with the βTS subunit pictured in blue (C) Reactions catalyzed by alpha and beta subunits of TS.
