Table 4.
Clinical and morphometrical comparisons between COVID-19 group (n=11) and Control group (n=11) placentas.
| Variable | Control | COVID-19 | p-value | |||
|---|---|---|---|---|---|---|
| Clinical data | Maternal | Maternal age (years) | 28.3 (18–42) | 33 (26–42) | 0.41 | |
| Gestational age (weeks) | 33.9 (23–39) | 33.6 (23–38) | 0.78 | |||
| Comorbidities | Hypertensive disorder (2) Gestational diabetes (2) Hypothyroidism (2) None (7) |
Hypertensive disorder (2)Gestational diabetes (2)Hypothyroidism (2) None (4) |
1 | |||
| Fetal | APGAR 1 min/5 min | 6.5 (2–9)/8.7 (7–10) | 6.6(0–9)/7 (0–10) | 0.59/0.48 | ||
| Fetal weight (grams) | 2656 (1,180–3,810) | 2213 (610–3,030) | 0.94 | |||
| Placental Weight (grams) | 395 (243–573) | 367 (135–650) | 0.87 | |||
| Fetal/Placental ratio | 6.74 (4.3–8.4) | 5.96(3.63–7.55) | 0.61 | |||
| Placental diameter (centimeters) | 16.45 (13–19) | 16.2 (12–20) | 0.88 | |||
| Infant death | 0 | 3 | 0.11 | |||
| Preterm newborn | 7 | 6 | 0.66 | |||
| Term newborn | 4 | 4 | 0.66 | |||
| Morphometric variables | HE | Villi number | 9.0 (5.3–14.5) | 8.3 (4.7–10.9) | 0.62 | |
| Knots/villus | 0.81 (0.6–1.0) | 0.81 (0.6–1.0) | 0.97 | |||
| Sprouts/villus | 0.16 (0.1–0.3) | 0.19 (0.1–0.5) | 0.92 | |||
| Villus diameter | 50.52 (43.4–58.8) | 51.4 (45.5–63.0) | 0.57 | |||
| Villus perimeter | 288.42 (202.7–368.5) | 271.93(213.8–358.4) | 0.37 | |||
| HPt | Fibrin area (µm2) | 485.36(61.9–1749.6) | 686.64 (170.3–2053.0) | 0.08 | ||
| SiriusRed | Collagen I percentage | 41.01(10.1–66.1) | 36.40(13.8–68.6) | 0.45 | ||
| Collagen III percentage | 58.99(33.9–89.9) | 63.60 (31.4–86.2) | 0.45 | |||
| Immunohistochemistry | CD68+ Hofbauer cell/villous | 1.2 | 1.7 | 0.12 | ||
p-value refers to the comparison between COVID-19 vs. the Control group; relevant values are highlighted (bold). p-value < 0.05. HPt, phosphotungstic hematoxylin.