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. 2021 May 26;12:676619. doi: 10.3389/fimmu.2021.676619

Figure 3.

Figure 3

Expression of regulatory cytokines according to treatment status. Association of treatment status (UNT = untreated, IFNB = interferon- β, FGLM = fingolimod) with (A) IL-10 plasma cytokine levels (NUNT = 40, NIFNB = 42, NFGLM = 29) and (B) the relative quantity (RQ) of IL10 (NUNT = 41, NIFNB = 40, NFGLM = 29), (C) RQ of IL12p35 (NUNT = 39, NIFNB = 38, NFGLM = 27) and (D) RQ of EBI3 (NUNT = 36, NIFNB = 38, NFGLM = 26). (E) Correlation of IL-10 with BAFF plasma levels. (F) Correlation of IL-10 plasma levels with the ratio of the mean fluorescence intensity (MFI) of TACI on BAFF-R on transitional B cells. P-values ≤ 0.05 are depicted. (A-D): P values were calculated from linear regression of the gene expression variable in function of treatment status (reference = UNT) with age and gender as a covariate. (E, F): P values were calculated with a linear regression of IL-10 levels in function BAFF/receptor expression levels with age, gender and treatment status as a covariate. Data points omitted in the sensitivity analysis are indicated with arrows. Box-whisker plots represent median, quartiles and 1.5 x IQR.