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. 2021 May 26;11:665192. doi: 10.3389/fonc.2021.665192

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Copyright © 2021 Li, Qin, Zhao, Cao, Yang, Wang, Li, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased the expression of METTL18 inhibits proliferation, invasion, and migration of liver cancer cells in vitro. (A) The expression of METTL18 in the HepG2, M97H, LM3, Bel7402, SK-HEP1, and Huh7 cell lines were detected by western blotting, respectively. (B) The transfection efficiency of si-METTL18 in the LM3 and Huh7 cell lines explores by western blotting. (C) The CCK-8 assay was applied to detect the efficiency of METTL18 knockdown on the proliferation of LM3 and Huh7 cell lines. (D) Images of the colony formation assay after knockdown of METTL18 in the LM3 and Huh7 cell lines. (E) Representational statistical analysis of the colony formation assay, including control, si-control, and si-METTL18 groups. (F) Representational images of the wound healing assay. (G) Statistical analysis of the wound healing assay results after decreased expression of METTL18. (H) Images of the transwell assay results after knockdown of METTL18 in the LM3 and Huh7 cell lines. (I) Representational statistical analysis of the transwell assay. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS, no significance.