Table 3.
Univariate and multivariate survival method (Overall Survival) of prognostic covariates in patients with hepatocellular carcinoma.
| Characteristics | Total(N) | HR (95% CI) Univariate analysis | P value Univariate analysis | HR (95% CI) Multivariate analysis | P value Multivariate analysis |
|---|---|---|---|---|---|
| T stage (T1 vs. T2&T3&T4) | 367 | 0.474(0.330-0.681) | <0.001 | 0.427(0.264-0.689) | <0.001 |
| N stage (N0 vs. N1) | 256 | 0.499(0.122-2.037) | 0.333 | ||
| M stage (M0 vs. M1) | 270 | 0.248(0.078-0.789) | 0.018 | 0.368(0.113-1.201) | 0.098 |
| Histologic grade (G1&G2 vs. G4&G3) | 365 | 0.893(0.623-1.281) | 0.539 | ||
| Vascular invasion (No vs. Yes) | 314 | 0.742(0.490-1.124) | 0.159 | ||
| Residual tumor (R0 vs. R1&R2) | 341 | 0.637(0.322-1.258) | 0.194 | ||
| Albumin(g/dl) (<3.5 vs. >=3.5) | 296 | 1.085(0.665-1.771) | 0.743 | ||
| AFP(ng/ml) (<=400 vs. >400) | 277 | 0.947(0.579-1.548) | 0.827 | ||
| TP53 status (WT vs. Mut) | 357 | 0.697(0.473-1.029) | 0.069 | 0.778(0.478-1.267) | 0.313 |
| Child-Pugh grade (A vs. B&C) | 238 | 0.619(0.305-1.254) | 0.183 | ||
| Race (Asian&Black or African American vs. White) | 358 | 0.803(0.559-1.153) | 0.235 | ||
| Adjacent hepatic tissue inflammation (None vs. Mild&Severe) | 233 | 0.815(0.501-1.325) | 0.409 | ||
| Age (<=60 vs. >60) | 370 | 0.802(0.565-1.136) | 0.214 | ||
| Gender (Female vs. Male) | 370 | 1.225(0.860-1.746) | 0.260 | ||
| Prothrombin time (<=4 vs. >4) | 293 | 0.752(0.496-1.140) | 0.179 | ||
| METTL18 (High vs. Low) | 370 | 1.870(1.309-2.671) | <0.001 | 2.485(1.523-4.053) | <0.001 |