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Effect of tunicamycin on the plasma levels of glucose and insulin in wild-type (WT) and MsrB3 knockout (KO) mice following consumption of a control diet or high-fat diet for 12 weeks. (A) MsrB3 mRNA and (B) protein levels in the gastrocnemius muscle. (C) Plasma glucose levels. (D) Plasma insulin levels. (E) Homeostatic model assessment-insulin resistance (HOMA-IR). Results are presented as means ± SE (n = 3–5 in each group). *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.
