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. 2021 May 26;8:683240. doi: 10.3389/fmolb.2021.683240

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Copyright © 2021 Xu, Hu, Chen, Zhu, Li, Shen, Guo, Sun, Chen, Jiang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of the prognostic risk signature based on DNA methylation. Kaplan–Meier curve analysis presenting difference of overall survival between the high-risk and low-risk groups in the training group (A), testing group (B), and combination cohort (C). ROC curve analysis of the risk scores for overall survival predictive significance in the training group (D), testing group (E), and combination cohort (F). The AUC was calculated for ROC curves, and sensitivity and specificity were calculated to assess score performance. Univariate Cox regression analyses of overall survival in the training group (G), testing group (H), and combination cohort (I). Multivariate Cox regression analyses of overall survival in the training group (J), testing group (K), and combination cohort (L).