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(A) Pyroptosis induce endothelial dysfunction, ECs death, inflammatory cytokines release and monocyte recruitment in at the early stage of atherosclerosis. (B) Pyrotosis induce foam cell formation and macrophage and SMC migration, increase inflammation and necrotic core formation in the advanced atherosclerosis. (C) Pyroptosis induce release of procoagulant molecules, thin the fibrous cap and promote plaque reptrue.
