Table 1.
Baseline characteristics of 240 HCC patients and univariate analysis of factors possibly affecting the survival.
| Variables | Number (%) | OS (P value) | RFS (P value) |
|---|---|---|---|
| Age (median, 50) | 0.091 | 0.227 | |
| <50 | 117 (48.8) | ||
| ≥50 | 123 (51.2) | ||
| Gender | 0.605 | 0.179 | |
| Male | 202 (84.2) | ||
| Female | 38 (15.8) | ||
| HBsAg | 0.010 | 0.052 | |
| Yes | 211 (87.9) | ||
| No | 29 (12.1) | ||
| Cirrhosis | 0.804 | 0.465 | |
| Yes | 150 (62.5) | ||
| No | 90 (37.5) | ||
| Portal hypertension | 0.616 | 0.506 | |
| Yes | 36 (15) | ||
| No | 204 (85) | ||
| AFP, ng/dL | 0.257 | 0.002 | |
| <400 | 139 (57.9) | ||
| ≥400 | 101 (42.1) | ||
| Tumor size, cm | 0.003 | 0.003 | |
| <5 | 104 (43.3) | ||
| ≥5 | 136 (56.7) | ||
| Tumor number | 0.031 | 0.014 | |
| Single | 193 (80.4) | ||
| Multiple | 47 (19.6) | ||
| Differentiation | 0.479 | 0.416 | |
| Well/Moderate | 148 (61.7) | ||
| Poor | 92 (38.3) | ||
| Macrovascular invasion | <0.001 | <0.001 | |
| Yes | 12 (5) | ||
| No | 228 (95) | ||
| Microvascular invasion | <0.001 | <0.001 | |
| Yes | 81 (33.8) | ||
| No | 159 (66.2) | ||
| BCLC stages | 0.002 | 0.004 | |
| 0-A | 185 (77.1) | ||
| B-C | 55 (22.9) | ||
| TNM stages | 0.127 | 0.127 | |
| I-II | 178 (74.2) | ||
| III | 62 (25.8) | ||
| pTLS | <0.001 | <0.001 | |
| Low | 89 (37.1) | ||
| High | 151 (62.9) | ||
| iTLS | 0.121 | 0.009 | |
| Present | 76 (31.7) | ||
| Absent | 164 (68.3) | ||
| GC | <0.001 | <0.001 | |
| Present | 106 (44.2) | ||
| Absent | 134 (55.8) |
AFP, alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer; TNM, tumor-nodes-metastasis; pTLS, peritumoral tertiary lymphoid structures; iTLS, intratumoral tertiary lymphoid structures; OS, overall survival; RFS, recurrence-free survival; HCC, hepatocellular carcinoma; GC, germinal center.