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. 2021 May 26;12:650425. doi: 10.3389/fphar.2021.650425

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Copyright © 2021 Li, Hu, Qian, Yao, Li, Yang, Yang, Yang, Zhou, Wang, Hu, Zhu, Zhou, Pan, Shen and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The future expectation of therapeutic methods in the treatment of COVID-19 patients. The researchers will specially use the gRNAs targeting both ORF1ab and S genes of SARS-CoV-2 in order to destroy the function of the virus and the toxicity of natural products by subtracting toxic genes through gene editing. Meanwhile, we can use the TCMSP database to predict and screen the effective active ingredients of related TCM and sort out the ingredients of each prescription respectively by using the network pharmacology method to treat COVID-19.