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. 2021 Jun 4;135(11):1389–1408. doi: 10.1042/CS20201394

Figure 2. Pro- and anti-inflammatory roles of cholesterol metabolism in disease.

Figure 2

Manipulating cholesterol metabolism may result in an overall pro- or anti- inflammatory phenotype, which can result beneficial or detrimental outcome in disease. Abbreviations: ACAT, acyl coenzyme A: Cholesterol AcylTransferase); IFNγ, interferon gamma; IL, interleukin; LXR, liver X receptor; MVK, mevalonate kinase; SREBP-2, sensor response element binding protein 2; TNFα, tumour necrosis factor alpha.