Fig. 3.
Effect of naproxen on cell proliferation markers (PCNA and cyclin D1) in KrasG12V mouse lung tumors. (A) Representative western blot and optical density of PCNA and cyclin D1 measured in total cell protein of tumors. (B-C) Representative photomicrographs showing immunohistochemical detection of PCNA labeling index and cyclin D1 (magnification 10X and 60X). Differences between control and treatment groups were analyzed by 1-tailed t test with Welch's correction and 95% confidence interval. Data represent Mean ± SEM. P ≤ 0.05 was considered statistically significant.