Fig. 4.
Effect of naproxen on apoptosis in KrasG12V mouse lung tumors. (A) Representative western blot of p21, caspase-3, and caspase-9 measured in total cell protein of tumors. (B-C) Representative photomicrographs showing immunohistochemical detection of p21 and caspase-3 (magnification 10X and 60X). (D) Representative photomicrographs showing calorimetric detection of apoptotic index through TUNEL assay. Differences between control and treatment groups were analyzed by 1-tailed t test with Welch's correction and 95% confidence interval. Data represent Mean ± SEM. P ≤ 0.05 was considered statistically significant.