Table 4.
Circadian single nucleotide polymorphism (SNPs) and cardiovascular risk factors in African Americans.
| Gene | SNP | Hypertension | Obesity | Dyslipidemia | Type 2 Diabetes | ||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | ||
| Clock | rs1801260 | 0.8229 | 0.2243 | 0.6965 | 0.02406 | 0.7357 | 0.07354 | NA | NA |
| rs4580704 | 1.075 | 0.6158 | 1.199 | 0.2011 | 1.18 | 0.2522 | NA | NA | |
| rs4864546 | 1.206 | 0.1466 | 0.97 | 0.8098 | 0.9915 | 0.9481 | 1.279 | 0.09609 | |
| rs10002541 | 1.069 | 0.6479 | 1.169 | 0.2765 | 1.187 | 0.2364 | 1.1 | 0.527 | |
| rs6850524 | 1.08 | 0.5595 | 0.7484 | 0.02575 | 0.9747 | 0.8475 | 0.8413 | 0.2624 | |
| Per3 | rs10462020 | 1.095 | 0.6883 | 0.8827 | 0.5736 | 0.7929 | 0.3299 | NA | NA |
| rs10462021 | 1.077 | 0.7446 | 0.8962 | 0.6222 | 0.8081 | 0.3715 | NA | NA | |
| rs228697 | 1.82 | 0.2238 | 1.04 | 0.9349 | 2.127 | 0.105 | NA | NA | |
| Cry1 | rs8192440 | 1.17 | 0.3786 | 0.8014 | 0.2047 | 0.7084 | 0.06335 | NA | NA |
| Cry2 | rs11605924 | 1.267 | 0.2656 | 1.45 | 0.07457 | 1.42 | 0.08673 | NA | NA |
| rs2292912 | 1.178 | 0.2725 | 1.263 | 0.1077 | 1.335 | 0.04985 | 1.489 | 0.01474 | |
| Bmal1 | rs11022775 | 0.9872 | 0.9273 | 1.209 | 0.1721 | 0.6972 | 0.01631 | 0.7471 | 0.09042 |
NA, not available.