Fig. 6.

Visualization of CD44 gene-centered significant long-range interactions in GM19240 Hi-C data A. Normalized Hi-C contact map (chr11:33,120,000–37,120,000) of GM19240 cell line and CD44 gene loci (translucent orange box). Scale bar indicates 500 kb distance. B. Genome tracks showing coverage normalized, distance-dependent signal normalized, interaction p-value, and false discovery rate (FDR) of CD44 gene-centered Hi-C interactions. Dashed lines indicate -log10(p-value) > 2 and -log10(FDR) > 2 threshold. C. Genome tracks showing H3K27ac, H3K4me3, H3K4me1, H3K9me3, and H3K27me3 level. D. Genome track showing location of GM12878 transcription factor clusters. E. Arcs indicating the significant interactions under different thresholds (blue: -log10(p-value) > 2 and purple: -log10(FDR) > 2). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)