Table 1.

Datasets used in this study.

#	Heavy metal	GEO ID	Platform used	Cell/ Cell line	Used form of heavy metal	Solution	Concentration	Procedure of exposure	Duration of exposure	References
1	As	GSE6907	Affymetrix Human HG-Focus Target Array	HepG2	As3+	Arsenic (III) oxide (As2O3) in Eagle’s Minimal Essential Medium (MEM)	20.0 μM	Cells were cultured in MEM supplemented with fetal bovine serum (FBS), nonessential amino acid, and kanamycin. As2O3 was added to culture medium as the culture reached ∼70% confluence	6 h	[100]
2	As	GSE8865	Affymetrix Human HG-Focus Target Array	HepG2	As3+	Arsenic (III) oxide (As2O3) in Eagle’s Minimal Essential Medium (MEM)	6.0 μM	Cells were cultured in MEM supplemented with fetal bovine serum (FBS), nonessential amino acid and kanamycin. As2O3 was added to culture medium as the culture reached ∼70% confluence	48 h	[101]
3	As	GSE48441	Affymetrix Human HG-Focus Target Array	HepG2	As3+	Arsenic (III) oxide (As2O3)	6.0 μM	N/A	48 h	N/A
4	As	GSE48441	Affymetrix Human HG-Focus Target Array	HepG2	As3+	Arsenic (III) oxide (As2O3)	0.5 μM	N/A	48 h	N/A
5	As	GSE136595	Agilent-028004 SurePrint G3 Human GE 8 × 60 K Microarray	MCF7	As3+	Sodium arsenite (NaAsO2) in Improved Minimal Essential Medium (IMEM)	1.0 μM	Cells were cultured in IMEM supplemented with FBS and glutamine. NaAsO2 was added to culture medium	24 h	[102]
6	As	GSE33520	Agilent-014850 Whole Human Genome Microarray 4 × 44 K G4112F	BEAS-2B	As3+	Arsenic (III) oxide (As2O3) spiking solutions in sterile PBS were diluted in fresh DMEM	2.5 μM	Cells were cultured in DMEM supplemented with FBS, L-glutamine and antibiotics (penicillin and streptomycin). As2O3 was added to culture medium	6 months	[103]
7	As	GSE36684	Affymetrix Human Gene 1.0 ST Array	BEAS-2B	As3+	Sodium arsenite (NaAsO2) was added to Dulbecco’s Modified Eagle’s Medium (DMEM) from a freshly prepared aqueous filter-sterilized solution	2μM	Cells were cultured in DMEM supplemented with FBS and antibiotics (penicillin and streptomycin). NaAsO2 was added to culture medium.	1−2months	[104]
8	As	GSE103873 (GPL16699)	Agilent-039494 SurePrint G3 Human GE v2 8 × 60 K Microarray	HepaRG	As3+	Sodium arsenite (NaAsO2) in William’s E Medium	1.0 μM	Cells were cultured in William’s E Medium supplemented with growth additives followed by differentiation agents. 3 or 14 days after the initial seeding, NaAsO2 was added to the media	>2 weeks	[80]
9	As	GSE103873 (GPL20884)	Agilent-072363 SurePrint G3 Human GE v3 8 × 60 K Microarray	HepaRG	As3+	Sodium arsenite (NaAsO2) in William’s E Medium	1.0 μM	Cells were cultured in William’s E Medium supplemented with growth additives followed by differentiation agents. 3 or 14 days after the initial seeding, NaAsO2 was added to the media.	>2 weeks	[80]
10	Cd	GSE31286	Agilent-014850 Whole Human Genome Microarray 4 × 44 K G4112F	HepG2	Cd2+	Cadmium chloride (CdCl2) in Opti-MEM medium	10.0 μM	Cells were cultured in Opti-MEM medium supplemented with FBS and antibiotics. CdCl2 was added in fresh Opti-MEM 1 day after seeding.	24 h	[105]
11	Cd	GSE6907	Affymetrix Human HG-Focus Target Array	HepG2	Cd2+	Cadmium chloride (CdCl2) in Eagle’s Minimal Essential Medium (MEM)	2.0 μM	Cells were cultured in MEM and CdCl2 was added to culture medium as the culture reached ∼70% confluence	6 h	[100]
12	Cd	GSE9951	Affymetrix Human Genome U133 Plus 2.0 Array	NPrEC	Cd2+	Cadmium chloride (CdCl2) in Defined Keratinocyte-SFM medium	2.5 μM	Cells were cultured in Defined Keratinocyte-SFM medium supplemented with growth-promoting factors. CdCl2 was added in fresh medium 3-days after seeding	16 h	[78]
13	Cd	GSE26828	Affymetrix Human Genome U133 Plus 2.0 Array	UROtsa	Cd2+	Cadmium chloride (CdCl2) in Dulbecco’s modified Eagle’s medium (DMEM)	1.0 μM	Cells were cultured in DMEM supplemented with FBS. CdCl2 was added to fresh culture medium	> 1 month	[106]
14	Cd	GSE31286	Agilent-014850 Whole Human Genome Microarray 4 × 44 K G4112F	HepG2	Cd2+	Cadmium chloride (CdCl2) in Opti-MEM medium	2.0 μM	Cells were cultured in Opti-MEM medium supplemented with FBS and antibiotics. CdCl2 was added in fresh Opti-MEM 1 day after seeding	24 h	[105]
15	Cd	GSE136595	Agilent-028004 SurePrint G3 Human GE 8 × 60 K Microarray	MCF7	Cd2+	Cadmium chloride (CdCl2) in Improved Minimal Essential Medium (IMEM)	1.0 μM	Cells were cultured in IMEM supplemented with FBS and glutamine. CdCl2 was added to culture medium	24 h	[102]
16	Cr	GSE6907	Affymetrix Human HG-Focus Target Array	HepG2	Cr6+	Potassium dichromate (K2Cr2O7) in Eagle’s Minimal Essential Medium (MEM)	20 .0μM	Cells were cultured in MEM, and K2Cr2O7 was added to culture medium as the culture reached ∼70% confluence	6 h	[100]
17	Cr	GSE16349	Sentrix Human Ref-8 v2 Expression BeadChip	Dermal fibroblast	Cr6+	Potassium dichromate (K2Cr2O7) in culture medium	5.0 μM	K2Cr2O7 was added to culture medium as the culture reached ∼70% confluence	16 h	N/A
18	Cr	GSE24025	Affymetrix Human Gene 1.0 ST Array	BEAS-2B	Cr6+	Potassium chromate (K2CrO4) in culture medium	0.25−0.5 μM	Cells were cultured in DMEM supplemented with FBS and antibiotics (penicillin and streptomycin). K2CrO4 was added to culture medium	1 month	[107]
19	Cr	GSE36684	Affymetrix Human Gene 1.0 ST Array	BEAS-2B	Cr6+	Potassium chromate(K2CrO4) was added to Dulbecco’s Modified Eagle’s Medium (DMEM) from a freshly prepared aqueous filter-sterilized solution	0.5 μM	Cells were cultured in DMEM supplemented with FBS and antibiotics (penicillin and streptomycin). K2CrO4 was added to culture medium	1−2 month	[104]
20	Fe	GSE16349	Sentrix Human Ref-8 v2 Expression BeadChip	Dermal fibroblast	Fe2+	Iron (II) sulfate (FeSO4) in culture medium	40 .0μM	FeSO4 was added to culture medium as the culture reached ∼70% confluence	16 h	N/A
21	Hg	GSE6907	Affymetrix Human HG-Focus Target Array	HepG2	Hg2+	Mercury (II) chloride (HgCl2) in Eagle’s Minimal Essential Medium (MEM)	20.0 μM	Cells were cultured in Eagle’s Minimal Essential Medium (MEM) and HgCl2 was added to culture medium as the culture reached ∼70% confluence	6 h	[100]
22	V	GSE36684	Affymetrix Human Gene 1.0 ST Array	BEAS-2B	V5+	Sodium metavanadate (NaVO3) was added to Dulbecco’s Modified Eagle’s Medium (DMEM) from a freshly prepared aqueous filter-sterilized solution	10.0 μM	Cells were cultured in DMEM supplemented with FBS and antibiotics (penicillin and streptomycin). NaVO3 was added to culture medium	1−2 month	[104]
23	Ni	GSE6907	Affymetrix Human HG-Focus Target Array	HepG2	Ni3+	Nickel (II) chloride hexahydrate (NiCl2 · 6H2O)	6.5 mM	Cells were cultured in Eagle’s Minimal Essential Medium (MEM), and As2O3 was added to culture medium as the culture reached 70% confluence	6 h	[100]
24	Ni	GSE8865	Affymetrix Human HG-Focus Target Array	HepG2	Ni2+	Nickel (II) chloride hexahydrate (NiCl2·6H2O)	150.0 μM	Cells were cultured in MEM supplemented with fetal bovine serum (FBS), nonessential amino acid, fetal bovine serum, and kanamycin. NiCl2·6H2O was added to culture medium as the culture reached ∼70% confluence	48 h	[101]
25	Ni	GSE36684	Affymetrix Human Gene 1.0 ST Array	BEAS-2B	Ni2+	Nickel sulfate (NiSO4) was added to Dulbecco’s Modified Eagle’s Medium (DMEM) from a freshly prepared aqueous filter-sterilized solution	250 μM	Cells were cultured in DMEM supplemented with FBS and antibiotics (penicillin and streptomycin). NiSO4 was added to culture medium	1−2 month	[104]