Table 8.

The cytotoxicity of NPs designed for brain delivery toward cell lines evaluated by the Lactate dehydrogenase (LDH) assay

NP formulation	90% Viability control NPs [µg mL−1]	Drug	90% viability for loaded NPs [µg mL−1]	Cell line	Size [nm]	Ref.
SLNP (DSPE)	1850	Functionalized with Apo E3+resveratrol	3700	hCMEC/D3	167.8 ± 19.9	[ 448 ]
SLNP (cetyl palmitate)	1500	Functionalized with ApoE3	1500	hCMEC/D3	192 ± 13	[ 433 ]
G3 PAMAM	700	Lauryl chains and paclitaxel	35	Porcine brain endothelial cells	13.7 ± 1.3	[ 449 ]
Cationic (cetyltrimethylammonium bromide) SLNPs	33	NA	NA	Human neutrophils	195	[ 450 ]
zero‐valent iron	20	α‐Synuclein amyloid	<20	SH‐SY5Y	83.88 a)	[ 451 ]
Single‐walled nanotubes	1	None	None	PC‐12	0.84 × 700–1000	[ 452 ]
Transferrin‐SLNP (cetyl palmitate)	ND	Quercetin	2400	hCMEC/D3	200	[ 453 ]
Nickel oxide	ND	NA	10	SH‐SY5Y	89.73 ± 5.98	[ 454 ]
Peptide nanofibers	ND	siRNA	11	hCMEC/D3	50 × 297	[ 455 ]

^a)This is hydrodynamic diameter, the actual NP diameter was 30 nm.