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. 2021 May 26;12:681223. doi: 10.3389/fphar.2021.681223

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Copyright © 2021 Sun, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lidocaine reduces the proliferation of ovarian and breast cancer cells in vitro. (A–H) SKOV-3 and T47D cells were treated with lidocaine (3 mM). (A,B) The cell viability was detected by MTT assays. (C,D) The cell proliferation was measured by colony formation assays. (E,F) The apoptosis was analyzed by flow cytometry. (G) The expression of Bcl-2, Bax, caspase3, and cleaved-caspase3 was detected by Western blot. The results were quantified using ImageJ software. (H) The expression of RIPK3 was measured by Western blot. The results were quantified using ImageJ software. mean ± SD, **p < 0.01. The experiments were performed independently three times.