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. 2021 May 26;12:681223. doi: 10.3389/fphar.2021.681223

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Copyright © 2021 Sun, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lidocaine inhibits SLC7A11 expression by upregulating miR-382-5p. (A,B) SKOV-3 and T47D cells were treated with lidocaine (3 mM). The expression of miR-382-5p was analyzed by qPCR assays. (C–F) SKOV-3 and T47D cells were treated with miR-382-5p mimic. (C,D) The luciferase activity of SLC7A11 mRNA 3’UTR was analyzed. (E,F) The mRNA levels of SLC7A11 were examined by qPCR. (G) The protein expression of SLC7A11 was detected by Western blot analysis in SKOV-3 and T47D cells co-treated with lidocaine and miR-382-5p inhibitor. (H) The expression of miR-382-5p and SLC7A11 was detected by qPCR in clinical ovarian cancer tissues (n = 38) and breast cancer tissues (n = 50) and the related adjacent tissues. mean ± SD, **p < 0.01. The experiments were performed independently three times.