FIGURE 5.

The inhibition of miR-382-5p blocks lidocaine-induced ferroptosis of ovarian and breast cancer cells. (A,B) The erastin (5 mmol/L) -stimulated SKOV-3 and T47D cells were co-treated with miR-382-5p inhibitor and lidocaine (3 mM). The cell viability was detected by MTT assays after 48 h of the treatment. (C–H) SKOV-3 and T47D cells were co-treated with miR-382-5p inhibitor and lidocaine. The Fe²⁺ (C,D), iron (E,F), and lipid ROS levels (G,H) were detected. mean ± SD, **p < 0.01. The experiments were performed independently three times.