. 2020 Dec;122:104914. doi: 10.1016/j.psyneuen.2020.104914

Table 3.

Associations between ACEs operationalisations and inflammation at age 9.

	IL-6 (n = 4935)				CRP (n = 4887)
	Crude model		Covariate-adjusted^a		Crude model		Covariate-adjusted^a
	% difference	95 % CI	% difference	95 % CI	% difference	95 % CI	% difference	95 % CI
ACE score
0 ACEs	Ref		Ref		Ref		Ref
1 ACE	3.28	−2.53, 9.43	2.31	−3.55, 8.51	1.66	−5.78, 9.68	1.09	−6.44, 9.21
2 ACEs	0.68	−6.88, 8.85	−0.92	−8.54, 7.32	−7.05	−16.13, 3.01	−7.80	−17.03, 2.45
3 ACEs	5.51	−5.80, 18.18	3.56	−7.73, 16.24	−0.31	−14.30, 15.97	−0.92	−15.08, 15.60
4+ ACEs	8.33	−0.30, 17.71	3.83	−5.16, 13.68	−6.80	−16.46, 3.97	−8.41	−18.73, 3.21
Individual ACEs
Parental separation/divorce	17.47	8.78, 26.85	14.31	5.44, 23.92	2.30	−7.57, 13.21	2.32	−8.03, 13.83
Parental alcohol problems	−13.57	−25.04, -0.34	−13.56	−25.05, -0.31	−6.64	−22.50, 12.47	−5.83	−21.86, 13.50
Maternal mental health problems	7.11	1.71, 12.80	5.59	−0.41, 11.95	−0.45	−7.02, 6.58	−0.91	−8.27, 7.05
Paternal mental health problems	−4.99	−11.52, 2.02	−7.41	−13.93, -0.40	−6.58	−14.96, 2.62	−6.63	−15.22, 2.82
Parental convictions	−20.35	−33.80, -4.16	−19.80	−33.35, -3.49	−8.55	−28.30, 16.65	−7.99	−27.91, 17.42
Inter-parental violence	9.61	−2.28, 22.95	6.83	−4.92, 20.04	0.49	−13.53, 16.78	0.73	−13.54, 17.36
Physical abuse	−0.73	−8.08, 7.20	−0.63	−8.05, 7.40	−0.60	−10.14, 9.95	0.39	−9.36, 11.19
Emotional abuse	−8.48	−15.54, -0.83	−9.36	−16.42, -1.70	−10.16	−19.15, -0.18	−9.75	−18.89, 0.41
Parental drug use	−3.78	−18.11, 13.05	−4.23	−18.51, 12.55	−17.77	−33.76, 2.08	−17.17	−33.32, 2.90
Sexual abuse	16.41	−26.17, 83.55	13.48	−28.02, 78.91	22.88	−32.23, 122.83	22.91	−32.27, 123.06
LCA-derived ACE clusters
Low ACEs (81.1 %)	Ref		Ref		Ref		Ref
Maternal mental health problems (10.3 %)	3.59	−4.10, 12.25	0.85	−7.11, 9.49	−8.23	−17.48, 2.06	−8.95	−18.35, 1.53
Maternal mental problems + physical abuse (6.3 %)	−6.03	−14.99, 3.87	−6.48	−15.50, 3.50	−5.12	−16.80, 8.19	−4.68	−16.58, 8.90
Parental conflict, mental health problems & emotional abuse (2.4 %)	15.20	−1.85, 35.22	8.03	−8.43, 27.45	4.98	−14.83, 29.44	4.09	−16.18, 29.26

Adjusted for overcrowding, maternal smoking during pregnancy, maternal EPDS score during pregnancy, mother’s marital status & mother’s highest educational qualification; Abbreviations: ACEs = adverse childhood experiences; CI = Confidence Interval; CRP = C-Reactive Protein; IL-6 = Interleukin-6.