IL-6 (n = 567)				CRP (n = 562)
	Crude model		Covariate-adjusteda		Crude model		Covariate-adjusteda
	logIL6	95 % CI	logIL6	95 % CI	logCRP	95 % CI	logCRP	95 % CI
ACE score
0 ACEs	Ref		Ref		Ref		Ref
1 ACE	0.03	−0.16, 0.21	0.01	−0.18, 0.20	0.07	−0.15, 0.30	0.08	−0.15 0.31
2 ACEs	−0.01	−0.23, 0.21	−0.03	−0.26, 0.20	0.02	−0.26, 0.29	0.04	−0.24, 0.32
3 ACEs	0.03	−0.22, 0.29	0.02	−0.24, 0.29	0.05	−0.27, 0.37	0.05	−0.28, 0.38
4+ ACEs	0.03	−0.26, 0.32	−0.03	−0.32, 0.27	0.15	−0.21, 0.50	0.12	−0.24, 0.48
Individual ACEs
Parental separation/divorce	0.23	−0.09, 0.54	0.26	−0.08, 0.59	0.17	−0.21, 0.56	0.22	−0.19, 0.64
Parental alcohol problems	−0.01	−0.25, 0.23	−0.06	−0.31, 0.20	0.001	−0.29, 0.30	−0.01	−0.32, 0.30
Maternal mental health problems	0.01	−0.14, 0.17	−0.01	−0.17, 0.15	0.02	−0.17, 0.21	0.04	−0.15, 0.23
Paternal mental health problems	0.01	−0.18, 0.19	−0.03	−0.22, 0.16	−0.04	−0.26, 0.18	−0.06	−0.29, 0.17
Parental convictions	−0.001	−0.32, 0.32	0.01	−0.31, 0.33	0.11	−0.28, 0.49	0.14	−0.25, 0.53
Inter-parental violence	0.09	−0.16, 0.34	0.07	−0.18, 0.33	0.14	−0.17, 0.44	0.10	−0.21, 0.41
Physical abuse	−0.001	−0.18, 0.18	0.004	−0.18, 0.19	0.02	−0.20, 0.24	0.04	−0.18, 0.26
Emotional abuse	−0.21	−0.41, -0.01	−0.23	−0.43, -0.02	0.07	−0.18, 0.32	0.02	−0.24, 0.27
Parental drug use	0.09	−0.23, 0.41	0.005	−0.33, 0.34	−0.07	−0.47, 0.34	−0.15	−0.57, 0.27
Sexual abuse	1.07	−0.69, 2.84	1.10	−0.66, 2.86	1.99	−0.16, 4.14	1.99	−0.17, 4.14
LCA-derived ACE clusters
Low ACEs (81.1 %)	Ref		Ref		Ref		Ref
Maternal mental health problems (10.3 %)	3.59	−4.10, 12.25	0.85	−7.11, 9.49	−8.23	−17.48, 2.06	−8.95	−18.35, 1.53
Maternal mental problems + physical abuse (6.3 %)	−6.03	−14.99, 3.87	−6.48	−15.50, 3.50	−5.12	−16.80, 8.19	−4.68	−16.58, 8.90
Parental conflict, mental health problems & emotional abuse (2.4 %)	15.20	−1.85, 35.22	8.03	−8.43, 27.45	4.98	−14.83, 29.44	4.09	−16.18, 29.26