Fig. 2.

Non-covalent strategies for the stabilization of particular oligomer populations, exemplified by nanobody- and metal ion-stabilized β₂m oligomers. A: Crystal structure of a dimer of a truncated β₂m variant (ΔN6-β₂m) stabilized by a nanobody (green) [28]. B: Crystal structure of a Cu²⁺-stabilized hexamer of the H13F β₂m variant. The Cu²⁺ ions are colored in orange [29]. In both A and B, β₂m protomers are shown in various shades of blue. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)