Table 1.
Clinicopathological characteristics of patients who underwent D2 radical gastrectomy with and without Tumor Deposits.
| All Gastrectomies |
TD∗ (-) |
TD (+) |
p-Value | |
|---|---|---|---|---|
| n† = 111 (100%) | n = 80 (72%) | n = 31 (28%) | ||
| Age‡, mean ± SD§ years |
60.9 ± 14.1 |
61.8 ± 14.2 |
58.4 ± 13.7 |
0.25 |
| Gender | ||||
| Male n (%) | 46 (41.4) | 28 (35) | 18 (58) | 0.02 |
| Female n (%) |
65 (58.6) |
52 (65) |
13 (42) |
|
| Tumor Location n (%) |
0.92 |
|||
| Distal | 57 (51.4) | 41 (51) | 16 (51.6) | |
| Middle | 45 (40.5) | 32 (40.3) | 13 (41.9) | |
| Upper |
9 (8.1) |
7 (8.7) |
2 (6.5) |
|
| Histological Subtype n (%) |
0.26 |
|||
| Tubular Adenocarcinoma | 51 (46) | 38 (47.5) | 13 (41.9) | |
| Signet Cell Carcinoma | 50 (45) | 33 (41.3) | 17 (54.8) | |
| Mixed Carcinoma |
10 (9) |
9 (11.3) |
1 (3.2) |
|
| Tumor Grade n (%) |
0.06 |
|||
| Well Differentiated | 13 (12) | 13 (16) | 0 | |
| Moderately Differentiated | 32 (28) | 22 (28) | 10 (32) | |
| Poorly Differentiated |
66 (60) |
45 (56) |
21 (68) |
|
| Neoadjuvant Chemotherapy n (%) | 0.53 |
|||
| No | 105 (94.5) | 76 (95) | 29 (93.5) | |
| Yes |
6 (5.5) |
4 (5) |
2 (6.5) |
|
| Depth of Invasion (pT) n (%) |
<0.001 |
|||
| T1a | 10 (9) | 10 (12.5) | 0 | |
| T1b | 10 (9) | 10 (12.5) | 0 | |
| T2 | 15 (13.5) | 13 (16.3) | 2 (6.5) | |
| T3 | 35 (31.5) | 28 (35) | 7 (22.5) | |
| T4a | 36 (32.4) | 18 (22.5) | 18 (58) | |
| T4b | 5 (4.5) | 1 (1.25) | 4 (13) | |
| Lymph Nodes Resected, mean ± SD |
69.5 ± 25.7 |
70.8 ± 26.8 |
66.4 ± 22.9 |
0.70 |
| Lymph Nodes Metastasis (pN) n (%) |
<0.001 |
|||
| N0 | 29 (26.1) | 27 (33.8) | 2 (6.4) | |
| N1 | 20 (18) | 16 (20) | 4 (12.9) | |
| N2 | 14 (12.6) | 10 (12.5) | 4 (12.9) | |
| N3a | 22 (19.8) | 17 (21.2) | 5 (16.2) | |
| N3b |
26 (23.4) |
10 (12.5) |
16 (51.6) |
|
| pTNM Stage n (%) |
0.001 |
|||
| Stage I | 25 (22.5) | 24 (30) | 1 (3.2) | |
| Stage II | 25 (22.5) | 20 (25) | 5 (16.1) | |
| Stage III |
61 (55) |
36 (45) |
25 (80.7) |
|
| Lymphovascular Invasion n (%) |
0.001 |
|||
| Present | 86 (77.5) | 55 (68.8) | 31 (100%) | |
| Absent |
25 (22.5) |
25 (31.2) |
0 |
|
| Perineural Invasion n (%) |
0.18 |
|||
| Present | 66 (59.5) | 45 (56.2) | 21 (67.7) | |
| Absent |
45 (40.5) |
35 (43.8) |
10 (32.3) |
|
| HER2 IHC Score System n (%) |
0.929 |
|||
| Negative Score 0 | 26 (23.4) | 18 (22.5) | 8 (25.8) | |
| Negative Score 1+ | 38 (34.2) | 28 (35) | 10 (32.2) | |
| Equivocal Score 2+ | 30 (27) | 21 (26.2) | 9 (29) | |
| Positive Score 3+ |
8 (7.2) |
5 (6.25) |
3 (9.6) |
|
| Type Of Gastrectomy |
0.33 |
|||
| Distal Gastrectomy n (%) | 59 (53.2) | 44 (55) | 15 (48) | |
| Total Gastrectomy n (%) |
52 (46.8) |
36 (45) |
16 (52) |
|
| Tumor Size, mean ± SD∥ |
5.7 ± 2.9 |
5.2 ± 2.8 |
6.96 ± 2.7 |
<0.001 |
| <5cm | 43 (53.8) | 5 (16.1) | ||
| ≥5cm | 37 (46.2) | 26 (83.9) | <0.001 | |
The values that are in bold are those that are statistically significant in the statistical analysis (p = <0.05).
∗
TD: Tumor deposits.
†
n: Number of patients.
‡
At the date of surgery.
§
SD: standard deviation.
∥
mean and standard deviation in centimeters.