Figure 3.

Unconjugated bile acids, notably LCA, expedite colonic transit (See also Figures S2,S4, and S7 and Table 1)

(A) Fecal LCA concentrations differ between mice colonized with the two BSH-high consortia.

(B) Intra-colonic bile acid infusions modulate gut transit.

(C) The pro-motility effect of lithocholic acid is inhibited by the TGR5 inhibitor SBI-115.

Statistical significance was determined using a two-tailed Student’s t-test (A) or paired two-tailed Student's t-test (B and C) as indicated in the text; ∗p< 0.05.

In (B), the horizontal lines within boxes denote the mean values, while lower and upper boundaries of boxes represent the 25th and 75th percentiles, respectively, and whiskers represent 1.5 times the interquartile range. In (A) and (C), mean values ± SEM are shown.