Table 1.

Predictions of the possible effects of the ATP2C2 missense variant (chr16:84405221)

Computational tool	Score (cut-off)a	Prediction
SIFT	0.24 (0 < s < 0.05)	Tolerated
Mutation assessor	1.535 (s > 3.5)	Low functional impact
PROVEAN	−0.399 (s ≤ −2.5)	Neutral
PolyPhen-2	0.002 (0.85 < s < 1.0)	Benign
MutPred	0.114 (s > 0.50)	Benign
INPS-MD	−0.073 (s < −0.5)	Weak destabilising effect
MutationTaster	21 (s ≥ 151)	Conservative

^aCut-off scores (s) for predicting functional effects.