Table 3.
Mean score of different phenotypes across carriers and non-carriers (ALSPAC cohort)
| Genotype (total N) | Mean score (SD; N) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Reading measures | Language measures | IQ | ||||||||
| READ | SPELL | PHONEME | NW_READ | WOLD | NWR | MEMSPAN | CCC_average7 | VIQ | PIQ | |
| GA or AA (42) | 26.6 | 6.4 | 17.8 | 4.3 | 7.6 | 7.2 | 3.3 | 31.1 | 104.4 | 97.4 |
| (9.8; 38) | (4.3; 37) | (9.5; 38) | (2.4; 39) | (1.8; 37) | (2.5; 37) | (0.8; 34) | (1.2; 37) | (13.6; 38) | (16.2; 39) | |
| GG (1825) | 30.1 | 8.3 | 21.2 | 5.5 | 7.8 | 7.5 | 3.5 | 31.3 | 112.1 | 103.7 |
| (8.7; 1707) | (4.3; 1696) | (9.4; 1710) | (2.4; 1763) | (1.9; 1711) | (2.4; 1711) | (0.8; 1622) | (1.1, 1722) | (16.6; 1703) | (16.8, 1701) | |
| P (t-test) | 0.016 | 0.006 | 0.026 | 0.002 | 0.533 | 0.503 | 0.131 | 0.311 | 0.006 | 0.022 |
Comparisons were evaluated with a Student’s t-test; P < 0.05 are indicated in bold. The threshold for Bonferroni correction based on 10 tests is 0.005.
Sample size varies depending on the availability of missing phenotypes. Details about each test can be found in Supplementary Material, Table S4.
READ, single-word reading accuracy; SPELL, single word spelling accuracy; PHONEME, phoneme awareness; NW_READ, nonword reading; WOLD, Listening and comprehension test; NWR, nonword repetition; MEMSPAN, working memory; CCC_average7, average of first seven scales from the Children’s Communication Checklist; VIQ, verbal IQ.