REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
mTOR (7C10) Rabbit mAb	Cell Signaling Technology,USA	Cat#2983;RRID: AB_2105622
Phospho-mTOR (Ser2448) (D9C2) XP® Rabbit mAb	Cell Signaling Technology,USA	Cat#5536; RRID: AB_10691552
HIF-1α (D2U3T) Rabbit mAb	Cell Signaling Technology,USA	Cat#14179; RRID: AB_2622225
Anti-β-Actin antibody, Mouse monoclonal	Sigma-Aldrich,USA	Cat#A1978; RRID: AB_476692
Chemicals, peptides, and recombinant proteins
Canagliflozin	Biochempartner, Shanghai, China	Cat# BCP38512
Rapamycin	MedChemExpress,USA	Cat#HY-10219
LW6	MedChemExpress,USA	Cat# HY-13671
Palmitic Acid	Sigma-Aldrich,USA	P0500-10G
Critical commercial assays
Evo M-MLV RT Premix RT-PCR kit	Accurate Biotechnology,Hunan,China	AG11728
SYBR Green Premix Pro Taq HS qPCR kit	Accurate Biotechnology,Hunan,China	AG11721
BNP Elisa Kit	YingxinBio,Shanghai,China	TX20633
LDH test reagent(kit)	BioSino,Beijing,China	E-BC-K044-S
Deposited data
mTOR FRB domain Structure	PDB	PDB:4DRI
Canagliflozin Structure	Drugbank	https://go.drugbank.com/drugs/DB08907
Dapagliflozin Structure	DrugBank	https://go.drugbank.com/drugs/DB06292
Empagliflozin Structure	DrugBank	https://go.drugbank.com/drugs/DB09038
Rapamycin Structure	Drugbank	https://go.drugbank.com/drugs/DB00877
Heart Failure Related Gene	GeneCards	https://www.genecards.org/Search/Keyword?queryString=heart%20failure
Diabetes Related Gene	GeneCards	https://www.genecards.org/Search/Keyword?queryString=diabetes
Experimental models: Cell lines
HL-1 Cell	Fenghui Bio,Hunan,China	CL0683
Experimental models: Organisms/strains
C57/BL6J Mice	Guangdong Medical Laboratory Animal Center	NO.44007200081314
High Fat Diets	Beijing HFK Bioscience, Beijing,Chima	H10141
Oligonucleotides
Primers for HIF-1a/IL-1a/IL6/TNF-a	This Paper	See Table 1
Software and algorithms
Cytoscape	(Bindea et al., 2009)	https://cytoscape.org/
Chimera 1.14	(Pettersen et al., 2004)	http://www.cgl.ucsf.edu/chimera/download.html
Swiss Target Prediction	(Daina et al., 2019)	http://www.swisstargetprediction.ch/
SwissDock	(Grosdidier et al., 2011)	http://www.swissdock.ch/