Skip to main content
. 2021 May 5;24(6):102515. doi: 10.1016/j.isci.2021.102515

Figure 2.

Figure 2

Propionate induces intestinal oxidative stress in the context of high-fat diet

(A–C) Intestinal biomarkers for oxidative stress in 1-month-old zebrafish fed the LFD, HFD, or HFSP0.5 for 2 weeks, including (A) mitochondrial ROS, (B) MDA, and (C) PC.

(D) Intestinal total antioxidant capability in 1-month-old zebrafish fed LFD, HFD, or HFSP0.5 for 2 weeks.

(E–G) Intestinal antioxidant enzymes in 1-month-old zebrafish fed the LFD, HFD, or HFSP0.5 for 2 weeks, including (E) Sod2, (F) Gpx, and (G) Cat.

(H) Representative histopathologic images of H&E-stained intestinal sections in zebrafish intraperitoneally injected with 4-hydroxy-TEMPO, a membrane-permeable radical scavenger. The scale bar, 50 μm.

(I) Histological score measuring the severity of the intestinal damage of zebrafish intraperitoneally injected with 4-hydroxy-TEMPO.

Values are means ± SEM (n = 5–12). Means without a common letter are significantly different (p < 0.05). Duncan's test.

See also Figure S3.