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. 2021 May 5;24(6):102515. doi: 10.1016/j.isci.2021.102515

Figure 8.

Figure 8

Gut microbiota indirectly activate mitochondrial death pathway

(A) The ROS level in GF zebrafish colonized with gut microbiota from 1-month-old zebrafish fed the LFD, HFD, or HFSP0.5 (n = 4–8).

(B–D) (B) Caspase-9, (C) caspase-6, and (D) caspase-3 activities in GF zebrafish colonized with gut microbiota from 1-month-old zebrafish fed the LFD, HFD, or HFSP0.5 (n = 4–6).

(E) Quantification of Sirt3 protein level in GF zebrafish transferred with gut microbiota from 1-month-old zebrafish fed the LFD, HFD, or HFSP0.5 (n = 4). Values are means ± SEM. Means without a common letter are significantly different ( p < 0.05). Duncan's test.