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. Author manuscript; available in PMC: 2021 Jun 9.
Published in final edited form as: Cancer Discov. 2020 Mar 18;10(6):806–821. doi: 10.1158/2159-8290.CD-19-1330

Figure 6.

Figure 6.

Restoration of PPP2R5A expression in Sf3b1 mutant Eμ-Myc tumors reduces tumorigenicity. A, Schematic representation of the study design. B, Confirmation of PPP2R5A expression in Cd19-cre+/− Sf3b1K700E/+ Eμ-MycTg/+ cells with expression of an empty vector (EV) or PPP2R5A cDNA. C and D, WBC (C) and PLT (D) counts of recipients (the mean value ± SD is shown). E, Representative photo of spleen (left) and spleen weight of recipients (right; the mean value ± SD is shown; an inch ruler is shown together). F, Percentages of GFP+ DAPI- cells in BM, spleen, liver, and PB (right) with representative flow cytometry analysis (left) (the mean value ± SD is shown). G, Kaplan-Meier curves of survival of recipients transplanted with Sf3b1K700E/+ Eμ-Myc tumor ± PPP2R5A expression (Log-rank (Mantel-Cox) test). *P < 0.05; **P < 0.01; ***P < 0.001.