Table 1.
General characteristics of individuals in the obesity cohort
| Variables | Total | Normal ALT | Mildly increased ALT | Markedly increased ALT | P value1 | P value2 | P value3 |
|---|---|---|---|---|---|---|---|
| >URL to < 2 x URL | ≥2 x URL | ||||||
| n = 11,776 | n = 6070 | n = 4461 | n = 1245 | ||||
| Males, n(%) | 6300 (53.5) | 3250 (53.5) | 2220 (49.8) | 830 (66.7) | < 0.001 | < 0.001 | < 0.001 |
| Age (years), mean (SD) | 11.0 (3.3) | 10.7 (3.3) | 11.1 (3.3) | 12.5 (3.3) | < 0.001 | < 0.001 | < 0.001 |
| 5- < 8 years, n(%) | 2574 (21.9) | 1526 (25.1) | 931 (20.9) | 117 (9.4) | |||
| 8- < 11 years, n(%) | 3427 (29.1) | 1761 (29.0) | 1365 (30.6) | 301 (24.2) | |||
| 11- < 14 years, n(%) | 3077 (26.1) | 1603 (26.4) | 1123 (25.2) | 351 (28.2) | |||
| 14- < 18 years, n(%) | 2698 (22.9) | 1180 (19.4) | 1042 (23.4) | 476 (38.2) | |||
| Degree of obesity | |||||||
| Class I obesity, n(%) | 6629 (56.3) | 3815 (62.8) | 2265 (50.8) | 549 (44.1) | < 0.001 | < 0.001 | < 0.001 |
| Class II obesity, n(%) | 3345 (28.4) | 1553 (25.6) | 1386 (31.1) | 406 (32.2) | |||
| Class III obesity, n(%) | 1802 (15.3) | 702 (11.6) | 810 (18.2) | 290 (23.3) | |||
Abbreviations: ALT alanine aminotransferase, SD standard deviation, URL upper reference level
Differences between groups were assessed using the chi-square test or independent t-test, where appropriate
1 Comparison between mildly increased ALT and normal ALT group
2 Comparison between markedly increased ALT and normal ALT group
3 Comparison between markedly increased ALT and mildly increased ALT group