Table 4.

ORs of mildly and markedly increased ALT^a for impaired fasting glucose and lipid profile

	Mildly increased ALT, n = 3527		Markedly increased ALT, n = 907
	OR (99% CI)	P value	OR (99% CI)	P value
Impaired fasting glucose	1.21 (0.91, 1.62)	0.085	1.62 (1.10, 2.40)	0.001
LDL
Acceptable	Ref		Ref
Borderline-high	1.20 (1.04, 1.39)	0.001	1.34 (1.06, 1.71)	0.002
High	1.41 (1.20, 1.65)	< 0.001	1.77 (1.38, 2.27)	< 0.001
Total cholesterol
Acceptable	Ref		Ref
Borderline-high	1.17 (1.02, 1.33)	0.002	1.20 (0.97, 1.50)	0.028
High	1.37 (1.14, 1.64)	< 0.001	1.80 (1.37, 2.36)	< 0.001
HDL
Acceptable	Ref		Ref
Low	1.25 (1.05, 1.49)	0.001	1.69 (1.33, 2.15)	< 0.001
Triglycerides
Acceptable	Ref		Ref
Borderline-high	1.16 (1.00, 1.34)	0.008	1.65 (1.28, 2.11)	< 0.001
High	1.78 (1.54, 2.05)	< 0.001	3.06 (2.44, 3.84)	< 0.001
HOMAb	1.06 (1.04–1.09)	< 0.001	1.13 (1.09–1.17)	< 0.001

Abbreviations: ALT alanine aminotransferase, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, HOMA homeostasis model assessment, OR odds ratio, CI confidence interval, Ref reference group

All ORs were adjusted for age, sex, and the degree of obesity

^a Compared to individuals with normal ALT

^b Analyses were based on 5262 individuals who had HOMA data (individuals with normal ALT, n = 2655; mildly increased ALT, n = 2047; markedly increased ALT, n = 560)