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. 2021 May 26;8:626328. doi: 10.3389/fmolb.2021.626328

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Copyright © 2021 Sun, Ge, Zhang, Yan, Wu, Ouyang, Wang, Ding, Zhang, Long, Liu, Shi, Zhou, Chen and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression profiles of copy number alterations (CNAs) of transcription factors (TFs) and relating overall survival analysis in clear cell renal cell carcinoma (ccRCC). (A) The CNA heatmap of 524 ccRCC tissue samples in the TCGA KIRC cohort shows most TFs are diploid, some TFs are heterozygous deletion (Hetloss) and low-level amplification (Gain), and a minority of TFs are homozygous deletion (Homdel) and high-level amplification (Amp). (B) Patients in Amp-high group (p = 0.048) and Hetloss-high group (p < 0.0001) have worse overall survival (OS), but no statistical difference was seen in Gain (p = 0.075) and Homdel (p = 0.16) groups.