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. 2021 May 26;12:676782. doi: 10.3389/fphys.2021.676782

Figure 2.

Figure 2

Predicted contributions of inflammation to high-altitude illnesses, erythrocytosis, and immune function. Hypoxic conditions lead to increases in pro-inflammatory mediators, which may play a role in the development of high-altitude illnesses [(Acute Mountain Sickness (AMS), high-altitude pulmonary hypertension (HAPH), high-altitude pulmonary edema (HAPE), and high-altitude cerebral edema (HACE)] and erythrocytosis, or modify immune function. (1) Julian et al. (2011); (2) Liu et al. (2017); (3) Wang et al. (2018); (4) Varatharaj and Galea (2017); (5) Wilkins et al. (2015); (6) Brito et al. (2020); (7) Mishra et al. (2016); (8) Song et al. (2016); (9) Zhou et al. (2017); (10) Jackson et al. (2010); (11) Liao et al. (2018); (12) Bennett et al. (2019); (13) Imagawa et al. (1990); (14) Haase (2013); (15) Kvamme et al. (2013); (16) Baze et al. (2011); (17) Facco et al. (2005); and (18) Feuerecker et al. (2019).