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Kinetics of bacterial burden in murine genital Chlamydia infection. Prior to activation of cell-autonomous immunity, C. trachomatis and C. muridarum grow unchecked inside genital epithelial cells. Innate IFNγ production induces expression of the IRG system, resulting in destruction of C. trachomatis but not C. muridarum. CD4 T cells ultimately clear genital C. muridarum infections after 4–7 weeks. Figure created with Biorender.com.
