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Characteristics of potential blocking antibodies
| Antibody | Expression level (mg/L) | SARS-CoV-2 RBD binding |
SARS-CoV-2 RBD blocking |
Epitope bin | Live virus neutralization Viral load reduction (Log10) |
|---|---|---|---|---|---|
| Affinity KD (nM) |
IC50 (nM) |
24 h | |||
| Ab2001.02 | 105 | 19.50 | 13.68 | 3 | 0.22 |
| Ab2001.03 | 116 | 10.90 | 5.85 | 3 | 0.18 |
| Ab2001.08 | 153 | 5.19 | 0.52 | 1 | 2.18 |
| Ab2001.09 | 112 | 11.90 | 3.13 | 2 | 2.10 |
| Ab2001.10 | 118 | 6.27 | 0.97 | 2 | 2.20 |
| 8 + 10 | NA* | NA | 1.67 | 1 + 2 | 2.13 |
| hACE2 | NA | 37.30 | 34.80 | NA | NA |
* NA: not applicable.
