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. 2021 Feb 19;17(7):2205–2215. doi: 10.1080/21645515.2020.1855952

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© 2021 Pfizer Inc. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Serum bactericidal antibody measurements against serogroup C at 1 month postprimary and postbooster vaccination in infants vaccinated with MenACWY-TT, MenC-TT, or MenC-CRM₁₉₇/Al(OH)₃ at 2, 4, and 12 months of age.⁶⁰ (a) Percentage of infants with rSBA titers ≥1:8, (b) rSBA GMTs, (c) percentage of infants with hSBA titers ≥1:8, and (d) hSBA GMTs.

Subjects had blood samples collected at 1 month (range, 21–48 days) after the second primary dose (primary ATP cohort) and the booster dose (booster ATP cohort). Panel A. Postprimary, n = 455–457; postbooster, n = 446–463. Panel B. Postprimary, n = 455–457; postbooster, n = 446–463. Panel C. Postprimary, n = 202–226; postbooster, n = 216–221. Panel D. Postprimary, n = 202–226; postbooster, n = 216–221. ATP = according to protocol; GMT = geometric mean titer; hSBA = serum bactericidal antibody using human complement; MenACWY-TT = meningococcal serogroups A, C, W, and Y vaccine conjugated to tetanus toxoid as a carrier protein; MenC-CRM₁₉₇/Al(OH)₃ = meningococcal serogroup C vaccine conjugated to the nontoxic form of diphtheria protein cross-reactive material 197 and adsorbed onto aluminum hydroxide; MenC-TT = meningococcal serogroup C vaccine conjugated to tetanus toxoid; rSBA = serum bactericidal antibody using baby rabbit complement.