Table 1.
Molecular characteristics of 20 isolates analyzed in this study: serogroup, genotype (cc, ST, porA-VR1, VR2, FetA) and 4CMenB antigen variants (fHbp, NHBA, NadA). hSBA titers for each isolate/pooled sera are shown. NCT01210885: Pooled sera derived from adolescents before and after one dose of MenACWY vaccine (n = 24); NCT00661713: Pooled sera derived from adolescents before and after two doses of 4CMenB vaccine administered 2 months apart (n = 39); NCT00657709: Pooled sera derived from infants before vaccination (n = 181); NCT00847145: Infants who received the primary series of 4CMenB plus the booster (n = 94)
|
NCT01210885 |
NCT00661713 |
NCT 00657709 |
NCT 00847145 |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype |
4CMenB antigen variant |
MenACWY adolescent |
4CMenB adolescent |
4CMenB infants |
|||||||||||||
| ID | Serogroup | CC | ST | PorA VR1 | PorA VR2 | FetA | fHbp variant | NHBA peptide | NadA variant | NadA peptide | PI | post1 | PI | post2 | PI | post4 | |
| IT_C1 | C | cc11 | ST-11 | 5 | 2 | F3-3 | 2.22 | 29 | 2/3 | 121 | <4 | >512 | <4 | 4* | <2 | <2 | |
| IT_C2 | C | cc11 | ST-11 | 5 | 2 | F3-3 | 2.22 | 29 | 2/3 | 121 | <4 | >512 | <4 | 4 | <2 | <2 | |
| IT_C3 | C | cc11 | ST-11 | 5 | 2 | F3-3 | 2.22 | 29 | 2/3 | 121 | <4 | >512 | <4 | 4* | <2 | <2 | |
| IT_C4 | C | cc11 | ST-11 | 5–1 | 10–8 | F3-6 | 1.13 | 20 | nadA gene contains IS element | <4 | >512 | <4 | <4 | <2 | <2 | ||
| IT_C5 | C | cc11 | ST-11 | 5–1 | 10–8 | F3-6 | 1.808 | 20 | nadA gene contains IS element | <4 | >512 | <4 | <4 | <2 | <2 | ||
| IT_C6 | C | cc11 | ST-11 | 5–1 | 10–8 | F3-6 | 1.808 | 20 | nadA gene contains IS element | <4 | >512 | <4 | <4 | <2 | <2 | ||
| IT_C7 | C | cc334 | ST-1031 | 7–4 | 14–6 | F3-9 | 2.19 | 6 | Frameshift in the nadA gene | <4 | 512 | <4 | 16 | <2 | 2 | ||
| IT_C8 | C | cc334 | ST-1031 | 7–4 | 14–6 | F3-9 | 1.13 | 6 | Frameshift in the nadA gene | <4 | >512 | <4 | 32 | <2 | 4 | ||
| IT_C9 | C | cc334 | ST-1031 | 7–4 | 14–6 | F3-9 | 2.1297 | 6 | Frameshift in the nadA gene | <4 | 256 | <4 | <4 | <2 | <2 | ||
| IT_C10 | C | cc11 | ST-11760 | 5–1 | 10–8 | F3-6 | 2.23 | 20 | nadA gene contains IS element | <4 | 256 | <4 | <4 | <2 | <2 | ||
| IT_C11 | C | cc11 | ST-11760 | 5–1 | 10–8 | F3-6 | 1.462 | 20 | nadA gene contains IS element | <4 | 128 | <4 | <4 | <2 | <2 | ||
| IT_W1 | W | cc11 | ST-11 | 5 | 2 | F1-1 | 1.9 | 96 | 2/3 | 6 | <4 | 256 | <4 | >128 | <2 | >64 | |
| IT_W2 | W | cc22 | ST-184 | 18–1 | 3 | F4-1 | 2.16 | 20 | Frameshift in the nadA gene | <4 | 256 | <4 | >128 | 8 | >64 | ||
| IT_X1 | X | cc181 | ST-181 | 5–1 | 10–1 | F1-31 | 1.74 | 359 | nadA gene contains IS element | <4 | <16 | <4 | >128 | 2 | 64 | ||
| IT_X2 | X | cc181 | ST-181 | 5–1 | 10–1 | F1-31 | 1.74 | 359 | Frameshift in the nadA gene | <4 | <16 | <4 | >128 | <2 | >64 | ||
| IT_Y1 | Y | cc23 | ST-23 | 5–2 | 10–2 | F2-13 | 1.393 | 8 | Frameshift in the nadA gene | <4 | 256 | 32* | >128 | <2 | >64 | ||
| IT_Y2 | Y | cc23 | ST-23 | 5–2 | 10–2 | F2-13 | 2.104 | 8 | nadA gene contains IS element | <4 | 128 | <4 | >128 | 4 | >64 | ||
| IT_Y3 | Y | cc23 | ST-23 | 5–2 | 10–2 | F4-1 | 3.29 | 8 | nadA gene contains IS element | <4 | 128 | <4 | 64 | 2 | 64 | ||
| IT_Y4 | Y | cc23 | ST-1655 | 5–1 | 10–1 | F4-1 | 2.25 | 7 | nadA gene contains IS element | 16* | 512 | 16 | >128 | 4 | >64 | ||
| IT_Y5 | Y | cc23 | ST-23 | 5–2 | 10–1 | F4-1 | 2.25 | 7 | Frameshift in the nadA gene | <4 | 128 | <4 | >128 | 4 | >64 | ||
* bacteriostatic.