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. 2021 May 26;11:667495. doi: 10.3389/fonc.2021.667495

Figure 1.

Figure 1

USP39 is upregulated in ESCC tissues and cell lines. (A, B) The relative expression of USP39 in ESCC tissues compared with normal tissues was analyzed using GEO datasets GDS3838 (A) and GSE23400 (B). Student’s t-test: *** p < 0.001. (C) Western blotting analyses of USP39 protein expression in ESCC (T) and paired adjacent normal tissues (N). USP39 protein expression levels were normalized to the GADPH loading control (n = 8 per group). (D, E) Representative immunohistochemical staining of USP39 expression in a matched pair of adjacent normal versus tumor tissues (D) and examples of high and low IRS scores in ESCC cancer tissues (E). (F) Western blotting analyses for USP39 expression in ESCC cell lines ECA109, KYSE30, KYSE70 and TE-13 compared with normal esophageal cell line Het-1A. (G) Kaplan-Meier curve showing a correlation of USP39 expression with disease free survival rate in ESCC patients.