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. 2021 May 26;12:628059. doi: 10.3389/fimmu.2021.628059

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Copyright © 2021 Giang, Horwitz, Bickerton and La Cava

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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aAPC NPs engineered to induce Tregs in vivo suppress lupus-like disease in NSG mice transferred with xenogenic human PBMCs. Six NSG mice per group were left untreated (no transfer) or injected with human PBMCs together with PBS (ctr) or aAPC NPs (see Methods). (A–C) Body weight change (A), clinical disease score (B) and Kaplan-Meier survival curves (C) at the time points indicated on the x axis. *P < 0.05 (aAPC NPs vs controls). (D, E) Comparisons between mice receiving aAPC NPs (NPs) or not (ctr) for skin appearance (D) and tissue histopathology of lung, liver and colon (20 x magnification) (E).