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. Author manuscript; available in PMC: 2022 Mar 19.
Published in final edited form as: ACS Chem Biol. 2021 Feb 22;16(3):520–528. doi: 10.1021/acschembio.0c00965

Figure 2. Temperature affects competition between SF3B inhibitors and inactive analogs.

Figure 2.

(a & b) Representative denaturing gels as described in Figure 1. Binding and competitions phases were 10 minutes at 4 or 30 °C with DMSO, HB (1 μM), PB (1 μM), SSA (1 μM) or iHB (100 μM). (c) Splicing efficiency quantified from denaturing gels as described in Figure 1. n.s. = p≥0.033, * p<0.033, ** p<0.002.