Table 1.

Design matrix and the responses for central composite blocked cube-star design for SFE

Run	Pressure (bar)	Time (min)	Modifier volume (µL)	Yield %
1	200	50	50	4.33
2	320	50	150	3.53
3	260	35	100	3.60
4	200	50	150	5.28
5	260	35	100	3.62
6	320	20	50	6.50
7	200	20	150	3.32
8	320	20	150	3.84
9	200	20	50	3.70
10	320	50	50	3.80
11	260	35	100	3.58
12	260	35	190	4.70
13	260	8	100	3.74
14	368	35	100	3.92
15	260	35	100	3.50
16	151	35	100	3.42
17	260	35	9	5.12
18	260	35	100	3.52
19	260	62	100	3.49
20	260	35	100	3.45