Fig. 2.

A network landscape of COVID-19 and neurological diseases. a Network proximity analysis shows strong network associations between COVID-19 and neurological diseases. Heatmap shows the “shortest” network proximities in Z score (see the “Materials and methods” section). Smaller Z scores indicate smaller network proximities between the two gene sets. b Protein-protein interaction network of the SARS-CoV-2 and other human coronaviruses host factors and the Alzheimer’s disease-associated genes/proteins. SARS-CoV-2 entry factors, antiviral defense genes, and AD biomarkers are highlighted by their gene symbols