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Light microscopy of the patient’s diffuse large B-cell lymphoma. (A) H&E-stained section shows large lymphoid cells with pleomorphic nuclei, variably prominent nucleoli, and scant to moderate amount of cytoplasm. (B) Immunostain for CD20 outlines the membranes of the large B cells. (C) Immunostain for Ki67 showing a proliferation rate of 80–90% of neoplastic lymphoid cells. (D) Immunostain for MYC, positive in 50–60% of neoplastic cells. All magnifications ×200.
