FIGURE 6.

Oviductal ablation of Igf1 increases developmentally delayed and nonviable embryos in mouse oviducts and inhibits embryo transport. A, Igf1 transcripts in Igf1^f/f (control) compared to Pgr^Cre/+; Igf1^f/f oviducts. B, Embryos collected from the uterus and/or oviduct from Igf1^f/f compared to Pgr^Cre/+; Igf1^f/f females at 3.5 days post coitus (dpc). C, Number of embryos at each developmental stage at 3.5 dpc. D, Number of developmentally delayed or nonviable embryos. P = .0595, unpaired Student’s t-test with Welch’s correction. E, Total number of all eggs or embryos present in the oviduct at 3.5 dpc. F, Number of embryos collected from Igf1^f/f (left bar) compared to Pgr^Cre/+; Igf1^f/f (right bar) at each region of the oviduct at 3.5 dpc. *P < .05, significantly different when compared to the corresponding Igf1^f/f mice, unpaired Student’s t-test with Welch’s correction. G, Percentage of mice with developmentally delayed or nonviable embryos in the oviduct. *P < .05, significantly different when compared to the corresponding Igf1^f/f group, Fisher’s exact test for contingency plot. n = 9–12 mice/genotype