Table 1. Description and frequency of baseline characteristics, comorbidity, clinical, laboratory variables in patients with thromboembolic events.
| All | Non-TEE | TEE | p-valuea | ||
|---|---|---|---|---|---|
| n (%) | 1737 | 1673 (96.3) | 64 (3.7) | - | |
| Age, mean (SD), years | 65.5 (16.7) | 65.3 (16.7) | 68.9 (14.0) | 0.097 | |
| Sex female | 686 (39.5) | 660 (39.5) | 26 (40.6) | 0.850 | |
| Hypertension | 647 (37.2) | 622 (37.2) | 25 (39.1) | 0.760 | |
| Diabetes | 263 (15.1) | 255 (15.2) | 8 (12.5) | 0.548 | |
| Hyperlipidemia | 390 (22.5) | 376 (22.5) | 14 (21.9) | 0.910 | |
| Chronic kidney disease | 64 (3.7) | 63 (3.8) | 1 (1.6) | 0.358 | |
| Congestive heart failure | 38 (2.2) | 35 (2.1) | 3 (4.7) | 0.164 | |
| Atrial fibrillation | 72 (4.1) | 70 (4.2) | 2 (3.1) | 0.677 | |
| Previous ischemic heart disease | 91 (5.2) | 89 (5.3) | 2 (3.1) | 0.439 | |
| Previous cerebrovascular disease | 15 (0.9) | 14 (0.8) | 1 (1.6) | 0.538 | |
| Pneumonia or respiratory symptoms | 1606 (92.5) | 1558 (93.1) | 48 (75.0) | <0.001 | |
| Chronic obstructive pulmonary disease | 119 (6.9) | 112 (6.7) | 7 (10.9) | 0.187 | |
| Ex-smoker | 258 (14.9) | 246 (14.7) | 12 (18.8) | 0.372 | |
| Current smoker | 52 (3.0) | 50 (3.0) | 2 (3.1) | 0.950 | |
| Management | |||||
| ICU admission | 117 (6.7) | 110 (6.6) | 7 (10.9) | 0.172 | |
| Days of hospitalization, median (IQR) | 7.0 (4.0–10.0) | 7.0 (4.0–10.0) | 7.5 (4.0–13.0) | 0.118 | |
| Death | 276 (15.9) | 257 (15.4) | 19 (29.7) | 0.002 | |
| Vital signs | |||||
| Systolic blood pressure, mean (SD) mmHg | N = 1099 | 131.5 (21.5) | 131.4 (21.4) | 132.2 (22.3) | 0.799 |
| Diastolic blood pressure, mean (SD) mmHg | N = 1104 | 76.5 (33.0) | 76.4 (33.6) | 78.6 (14.2) | 0.643 |
| Oxygen saturation, mean (SD) | N = 1385 | 92.3 (7.0) | 92.3 (7.0) | 91.4 (7.4) | 0.357 |
| Laboratory determinations | |||||
| D-dimer, median (IQR) ng/mL | N = 257 | 822.5 (450.5–1745.5) | 742.5 (425.0–1496.0) | 6679.0 (661.0–11297.0) | 0.009 |
| Alanine aminotransferase, median (IQR) U/L | N = 277 | 28.2 (17.0–49.0) | 27.1 (17.0–46.7) | 37.0 (23.8–67.1) | 0.343 |
| Aspartate aminotransferase, median (IQR) U/L | N = 284 | 34.0 (23.8–57.1) | 33.0 (23.3–56.3) | 43.5 (25.0–78.2) | 0.265 |
| Creatinine, median (IQR) mg/dL | N = 304 | 0.9 (0.7–1.1) | 0.9 (0.7–1.1) | 0.8 (0.7–0.9) | 0.232 |
| Hemoglobin, median (IQR) g/dL | N = 297 | 13.6 (12.2–14.8) | 13.7 (12.5–14.8) | 14.1 (11.6–15.9) | 0.696 |
| Leukocytes, median (IQR) x10e3/μL | N = 308 | 6.6 (5.0–9.5) | 6.4 (4.9–8.9) | 6.8 (5.0–9.1) | 0.857 |
| Neutrophil count, median (IQR) x10e3/μL | N = 308 | 4.8 (3.3–7.6) | 4.6 (3.3–7.1) | 4.9 (3.3–7.6) | 0.772 |
| Platelet count, median (IQR) x103 per uL | N = 302 | 218.5 (168.3–299.5) | 214.0 (165.5–301.0) | 240.0 (209.5–271.5) | 0.493 |
| C reactive protein, median (IQR) mg/dl | N = 288 | 61.8 (24.2–118.6) | 60.3 (22.9–122.2) | 89.5 (33.0–135.7) | 0.279 |
| Prothrombin time, median (IQR) s | N = 259 | 13.2 (12.3–14.5) | 13.3 (12.4–14.6) | 12.6 (11.9–13.2) | 0.056 |
Values are presented as n (%) or mean ± SD unless otherwise stated. Statistically significant results are highlighted in bold. Abbreviations: Non-TEE: non-thromboembolic event. TEE: thromboembolic event. Reference ranges are as follows: d-dimer, 0 to 500 ng per milliliter; alanine aminotransferase (ALT), U/L <33–41; aspartate aminotransferase (AST), U/L <33–41; creatinine, mg/dL (0.7–1.2) mg/dL (0.5–0.9); hemoglobin, g/dL (12.3–15.3) (14.0–17.5); leukocytes, x10e3/μL (4.4–11.3); neutrophil count, x10e3/μL (1.5–7.5); platelet count, 150,000 to 450,000 per cubic microliter; C reactive protein, mg/L <5; prothrombin time, 9.9 to 14.2 seconds.
Abbreviations: SD, standard deviation; IQR, interquartile range; ICU, intensive care unit.