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. 2021 May 26;8:685362. doi: 10.3389/fmolb.2021.685362

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Copyright © 2021 Zhou, Lu, Huang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Venn diagrams of characteristic metabolites identified from pairwise comparisons of CIS vs. NOR and TAU vs. CIS. Characteristic metabolites were determined by a combination of the significant metabolites identified from the PLS-DAs (VIP >1) and differential metabolites identified from the univariate analyses (p < 0.05). The upward arrow and downward arrow denote that the difference between A and B is positive (A is increased compared to (B)) and negative (A is decreased compared to (B)), respectively. The metabolites in red font refer to shared characteristic metabolites in the two comparisons.