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. 2021 May 26;8:685362. doi: 10.3389/fmolb.2021.685362

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Copyright © 2021 Zhou, Lu, Huang and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Significantly altered metabolic pathways identified from pairwise comparisons of CIS vs. NOR and TAU vs. CIS. The significant pathways were identified with pathway impact values >0.2 and p values <0.05, using the Pathway Analysis module provided by MetaboAnalyst 4.0 webserver. Numbers in the panels represent significantly altered metabolic pathways: (1) glycine, serine, and threonine metabolism; (2) alanine, aspartate, and glutamate metabolism; (3) phenylalanine, tyrosine, and tryptophan biosynthesis; (4) phenylalanine metabolism; (5) glutathione metabolism; (6) starch and sucrose metabolism; (7) D-glutamine and D-glutamate metabolism; (8) β-alanine metabolism; and (9) histidine metabolism.